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In vitro co-immunoprecipitation and fluorescence polarisation assays have investigated the binding affinity of Proxofim for the p53 interaction domain, examining whether the DRI construct competitively displaces endogenous FOXO4 from the FOXO4-p53 complex in senescent fibroblast cultures

Depletion of PHD3 protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis

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