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This can cause the estrogen metabolites to be reabsorbed from the intestines and go back into circulation.[ref] Calcium D-glucarate can suppress the beta-glucuronidase activity in the gut, thus increasing the number of estrogen metabolites that are excreted.[ref] Hormone Replacement Therapy: Hormone replacement therapy (HRT) in menopause is the replacement of naturally declining estrogen and progesterone levels with either synthetic or bioidentical hormones

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doi:10.1074/jbc.M805586200, PMID: 18990698 Mieyal JJ, Starke DW, Gravina SA, Hocevar BA (1991) Thioltransferase in human red blood cells: kinetics and equilibrium