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He stated, Semaglutide 2.4 mg not only reduces the first event risk but also lowers the cumulative cardiovascular burden making it a foundational therapy for secondary prevention in obesity-related cardiovascular disease Vince Lamanna, President of Novo Nordisk Canada, commented that these results expand the meaning of cardiovascular care by integrating obesity treatment as a proven strategy to prevent future events. He highlighted that Health Canadas decision to approve semaglutide 2.4 mg for patients with established CVD and overweight or obesity was the first global regulatory recognition of obesity therapy as a cardiovascular indication
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57,58 Glycolytic products activate the tricarboxylic acid cycle in the mitochondria which leads to electron transport across the electron transport chain resulting in the production of a protonmotive force and subsequent ATP production via ATP synthase activity
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