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In preclinical and in vitro systems, IGF-1 LR3 is commonly used to explore mechanisms of cell proliferation and differentiation, myostatin-related signaling in muscle biology, and metabolic processes involving glucose handling and lipid mobilization

However, HFpEF is a heterogeneous condition and its numerous phenotypes include obesity-related, MetS-related, age-related, arterial stiffness-related, and CKD-related HFpEF, which can overlap [66]

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