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Because estradiol modulates hepatic synthesis of angiotensinogen and clotting factors II, VII, IX, and X, blood pressure elevation and thromboembolic events, though infrequent, remain clinically relevant

Some patients may have conditions that make semaglutide unsuitable, including personal or family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2

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More structural improvementslike tendon or ligament integrity, joint function, and enduranceoften develop over 812 weeks as collagen architecture and circulation improve