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A randomized controlled trial using a fractional factorial design showed that compared with placebo, the combined supplementation with riboflavin (3 mg/day) and niacin (40 mg/day) for five to six years reduced the prevalence of nuclear cataract but increased the progression of posterior subcapsular cataracts in population affected by multiple nutrient deficiency living in rural China (38)

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Studies suggest that expression of GSTs is induced by various environmental stimuli, including biotic stresses such as fungal elicitors and pathogen attack (Xu et al., 2015), H 2 O 2 (Levine et al., 1994), hormone treatments (Wagner et al., 2002