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The study measured penile rigidity and levels of sexual desire, while side effects were self-reported

Similar strategies may also be used to deplete IgA, as explored with the pre-clinical candidate BHV-1400 [434], which leverages ASGPR biology in a manner similar to BHV-1300 and could represent an alternative to the likely mechanism-of-action of ARGX-121, and to deplete IgE, as shown with lysosomal targeting chimeras coupling pH-sensitive target binding and ASGPR-mediated endolysosomal delivery to FcRn-mediated cellular transport of the potential therapeutic molecule [435]

Industry leaders like Novo Nordisk and Eli Lilly are leading the charge

The body's adaptive mechanisms also kick in over time, potentially reducing the drug's effectiveness if doses are stacked too closely together