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A Canadian Public Health Association article published by McMaster University Master of Public Health candidate Sadiqa Sheikh states that an estimated 3 million Canadian adults are taking GLP-1 receptor agonists as of early 2026, making Canada the second-largest user of GLP-1s in the world [Source: cpha.ca/glp-1-agonists-and-obesity-public-health-perspective]

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They demonstrated that human pancreatic tumor and stellate cells activate/process GSAO into its active metabolite and that GT activity positively correlates with GSAO-mediated proliferation arrest of co-cultured endothelial cells ( Figure 3B )