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In PIONEER 3 for example, between 10% and 34% of patients in all treatment groups required rescue medication at week 78

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The action of SNAC is time- and concentration-dependent and is fully reversible.[11] In various pharmacological studies, the dose of SNAC has been from 150 to 600 mg and it has been found that 300 mg of SNAC is the optimum dose to get maximum bioavailability

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