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Skeletal muscle, ligament, and bone-defect models have produced comparable healing-rate findings, summarized in the 2021 wound-healing review (PMID 34267654) and the 2025 musculoskeletal narrative review (PMID 40789979)

The liver and kidneys then convert it into its active hormonal form, calcitriol , which binds to vitamin D receptors in cells and regulates over 1,000 gene expressions related to bone health, immunity, and cellular function

The formula is: Dose in mg / Concentration in mg/mL = Volume in mL

These injections can be given in various dosages and schedules, depending on the severity of the deficiency and the patient's response to treatment