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Christopher Margrey, DVM

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Common Adverse Effects According to pharmaceutical research on semaglutide, gastrointestinal effects are most frequent: nausea (20-44% incidence, usually mild-moderate, improves over time), vomiting (9-24% incidence), diarrhea (20-30% incidence), constipation (20-24% incidence), and abdominal pain (8-20% incidence)

Gopal Grandhige, MD, FACS, Board-Certified Surgeon Last Reviewed: March 16, 2026 BPC-157 typically begins working within the first one to two weeks, with most patients noticing subtle improvements such as reduced soreness, better digestion, and decreased inflammation during this early phase