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Whereas the GLP-1R has been broadly found across most types of neuronal cells within the brain, spinal cord, and ganglion and peripheral nerve 1,89,91 , with GLP-1 agonsits enhancing neuronal phenotypic markers (e.g., augmenting choline acetyltransferase levels in cholinergic cells and TH levels in DAergic neurons 35,91 ), there is increasing evidence that astrocytes likewise express GLP-1Rs and that injury and neuroinflammation elevate their expression

JAMA 2015

Moreover, the hydroxyl radical and singlet oxygen disrupt the functions of deoxyribonucleic acid (DNA)-protein crosslinking, distorting the DNA restoration mechanism [8]

L- , (BCAA)