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Systemic Side Effects Gastrointestinal Side Effects The most commonly reported side effects of GLP-1 RAs are gastrointestinal, including nausea, vomiting, diarrhea, constipation, abdominal pain, and dyspepsia [113,114,115]

Semaglutide operates through GLP-1 hormone pathways, while antidepressants work on neurotransmitters like serotonin, so direct chemical interference is unlikely

For people who are significantly overweight, bariatric surgery and a new class of drugs called glucagon-like peptide-1 receptor agonists (GLP-1) are changing the game and sparking hope for a healthy future

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