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Interestingly, the reduced glucose absorption associated with pharmacological or genetic inhibition of SGLT1 results in a sizeable second phase GLP1 release, suggesting that increased glucose transit activates distal Lcells and releases GLP1 via a SGLT1independent mechanism (Powell et al., 2013)

Early trial data showed approximately 13% weight loss at 12 weeks, a pace that projects to potentially 25-30%+ at full treatment duration