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Thus, increased expression of HSPs as a protective stress response may inadvertently prime beta cells for immune destruction, creating a vicious cycle in which cellular stress enhances autoimmunity targeting [93]

doi:10.1074/jbc.M809338200, PMID: 19176520 Suthanthiran M, Anderson ME, Sharma VK, Meister A (1990) Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens

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The epithelial cell leak pathway