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Indeed, a common observation in mouse lines lacking IGF-1 (and/or its receptor) is that embryonic development is impaired but embryos are viable

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Effect of drought stresses on AsA-GSH cycle enzymes activities MDHAR, DHAR, APX and GR activity progressively augmented with the increment of drought stress under MDS and SDS conditions in comparison with control treatment in the tolerant genotype VA13, while the increments of those enzymes activities were much lower in the sensitive genotype VA15 compared to tolerant genotype VA13 at all drought stress levels (Fig