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Subjects received a 16 mg afamelanotide subcutaneous implant or placebo every 60 days (Langendonk et al., 2015)

Structural requirements for the activation of the human growth hormone secretagogue receptor by peptide and nonpeptide secretagogues

Peptide therapy for body composition may be appropriate for patients who: Have high visceral fat on imaging Plateaued with traditional weight loss Lost muscle mass on GLP-1 therapy Show low-normal IGF-1 Want a longevity-based metabolic strategy Are healthy individuals seeking to optimize body composition and longevity, under medical supervision It is not a quick fix

High-intensity exercise places substantial demands on cardiac output, stimulating robust protein synthesis in cardiomyocytes, which facilitates cellular growth and suppresses apoptosis (134)