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However, the effect of GLP-1RAs on hepatic fibrosis seems to be minimal, which is in line with major clinical trials on the effect of liraglutide [49] and semaglutide [50] in patients with NASH

Individualized dosing, regular laboratory monitoring (particularly IGF-1 levels), and physician oversight are key to maintaining safety and optimizing therapeutic benefit

mice, zebrafish, and clawed frogs) the threonine aldolase gene encodes a functional threonine catabolizing enzyme

Since the first semaglutide drug was approved in 2005, patients and manufacturers have seen many changes: shortages, compounding, and more than a thousand lawsuits from patients who experienced severe side effects under these drugs, including stomach paralysis, bowel obstruction, and vision loss