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Clinicians need to balance continued metabolic advantages against changed physiology that may increase anesthetic and operative hazards

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It is suggested that blood glucose and insulin levels should be monitored during its administration due to the risk of progression to glucose intolerance or the development of T2D, especially in genetically predisposed individuals ( 2.6 Role of growth hormone in the aging brain The role of HGH extends beyond body growth and metabolism, affecting several neuroendocrine and cognitive functions