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In a study also published in The New England Journal of Medicine a few months later in June 2021, those taking 5mg lost about 7.8kg (about 17lbs), those with 10mg lost 10.3kg (about 22.7lbs), and those on 15mg lost 12.4kg (about 27lbs)

By keeping the stool soft and moving, you may reduce the theoretical risk of a fecalith obstructing the appendix

Eur Heart J 34(40):31003101 Davison BA et al (2020) Mega-trials in heart failure: effects of dilution in examination of new therapies