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NMR validation of 1907 interactions and circular dichroism To validate the binding mode of 1907 and map its interactions with the FAT domain, we performed heteronuclear single quantum coherence-nuclear magnetic resonance (HSQC-NMR) chemical shift perturbation (CSP) studies with 15 N labeled recombinant FAT protein and titrating amounts of 1907 from 100 nM to 200 M (Fig

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Clinical studies using fluorodeoxyglucose FDG and positron emission tomography (FDG-PET) imaging studies in subjects with AD have shown reduced glucose transport and glucose metabolism in the areas most affected by AD (88)

Electrophysiological recordings demonstrate that Dihexa-treated neurons exhibit significantly increased frequency of miniature excitatory postsynaptic currents (mEPSCs), indicating enhanced synaptic transmission