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Conclusions Subcutaneous infusion using a subcutaneous catheter system and a portable pump for OHCbl administration in combined and isolated remethylation disorders is safe, acceptable, and effective

Some vitamins cannot be delivered directly into a vein and thus require injection into the muscle or fat layer beneath the skin

Commenters noted that this product's pass-through status expired June 30, 2025, and that it was previously indicated as a cell and gene therapy that would be excluded from C-APC packaging

[DOI] [PubMed] [Google Scholar] 128.Chen C.L., Lin C.F., Wan S.W., Wei L.S., Chen M.C., Yeh T.M., Liu H.S., Anderson R., Lin Y.S