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An anti-ASCT2 monoclonal antibody suppresses gastric cancer growth by inducing oxidative stress and antibody dependent cellular toxicity in preclinical models

Sakurabayashi T, Takaesu Y, Haginoshita S et al (1999) Improvement of myocardial fatty acid metabolism through L-carnitine administration to chronic hemodialysis patients

Clinical trials show that patients who follow a gradual escalation schedule report better tolerability and higher medication adherence than those who jump to higher doses immediately

These ROS oxidize PUFAs in cell membranes into lipid peroxides (PUFA-OOH), thereby destroying cell membrane structural stability, attacking cellular DNA and proteins, and causing ferroptosis