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2 In cell and tissue studies it does genuinely interesting things: it modulates the synthesis and breakdown of collagen and glycosaminoglycans, influences matrix metalloproteinases and their inhibitors, stimulates decorin and other proteoglycans, and, in gene-expression analyses, shifts the activity of a large number of genes in a direction associated with tissue remodeling and antioxidant defense

Beyond their primary role in glucose control, GLP-1 drugs offer additional benefits, including appetite suppression and subsequent weight loss

it has been closely correlated to the PCOS phenotype of obesity and insulin resistance [54] while also increasing the probability of cardiovascular disease in women with PCOS [57]

While genetic variants do not predict exact semaglutide response, they may help provide context for provider conversations about whether standard 4-week titration schedules align with your metabolic profile or warrant alternative timing strategies