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Caffeine may also enhance endurance and strength by increasing fatty acid oxidation and sparing muscle glycogen [29]

In such cases, the subject still technically has PD, but the quality of life of the subject is significantly improved because the progression of symptoms is slowed, or even stopped (arrested) at an earlier stage than would be possible without administration of the HGF mimic(s), e.g

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Importantly, RRM2 is often found overexpressed in NB, and its depletion was shown to induce G1/S phase arrest due to replicative stress and checkpoint kinase 1 (CHK1) activation (47, 48)