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PAGln inhibits myocardial contraction via 2AR signaling, while concurrently activating pathways that exacerbate oxidative stress, calcium dysregulation, and electrophysiological abnormalities, ultimately accelerating thrombosis and structural remodeling

The PSM was performed using 1:1 to reduce the confounding effects

Chang et al., using proteomic techniques, compared the expression differences of TF and TfR1 in the brains and peripheral blood of normal mice and chronic social defeat stress (CSDS)-induced depression mouse models