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The study has also determined that rs2476601 within PTPN22 was the best predictor for insulin AAb appearing first and that rs231775 at CTLA4 is correlated with GAD AAb at initial seroconversion (243)

10.1373/clinchem.2014.235986 Summary Keywords oxidative stress, ME/CFS, Gulf War Syndrome, fibromyalgia, energy metabolism, lipid dysregulation Citation Davis L, Higgs M, Snaith A, Lodge TA, Strong J, Espejo-Oltra JA, Kujawski S, Zalewski P, Pretorius E, Hoerger M and Morten KJ (2025) Dysregulation of lipid metabolism, energy production, and oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome, Gulf War Syndrome and fibromyalgia

Therefore, we explicitly state that larger clinical studies are imperative to rigorously establish the safety and efficacy of these approaches in humans