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Chem Res Toxicol 27:169171 Sherman BT, Hao M, Qiu J, Jiao X, Baseler MW, Lane HC et al (2022) DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)

Most of these are mild and manageable

MuRF-1 and MAFbx/Atrogin-1 (E3 ubiquitin ligases mediating myofibrillar proteolysis) are suppressed 3442% in IGF-1 LR3-treated myotubes under dexamethasone-induced atrophy conditions (1 M Dex, 24 h), demonstrating anti-atrophy activity via Akt-dependent FoxO1/FoxO3a phosphorylation (nuclear exclusion +3844%)

Although most studies have not extended beyond a year after withdrawal, the results suggest that improvement continues beyond this time