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The primary composite outcome was major adverse CV events, defined as nonfatal myocardial infarction, nonfatal stroke or all-cause mortality

In a study, stopping semaglutide treatment after ~68 weeks resulted in weight regain, though even at 120 weeks, there was still a net loss compared to baseline (but less than at peak)

Last reviewed: May 18, 2026 Last updated: May 18, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

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