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In susceptible patients, these pressures may increase mitochondrial stress, raise SAH, lower the SAM-to-SAH ratio and create a functional undermethylation pattern that contributes to depression, anxiety, brain fog, fatigue and medication sensitivity

B12 supports energy metabolism, and deficiency can cause fatigue

Its safer to get these types of medications from a trusted clinical source like a doctor or provider team than from other settings like unregulated med spas or online retailers, Harris said

Others favor lifestyle or hormonal methods instead, which is understandable in light of variable results between people