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Furthermore, GLP-1 decreases glucagon secretion from pancreatic cells and has also extrapancreatic influences as a direct suppressive effect on appetite centers and a slowing of gastric emptying increasing the feeling of satiety

Mechanism of Action Retatrutide simultaneously activates three metabolic receptors, distinguishing it from dual agonists such as tirzepatide (GLP-1/GIP only) and single agonists such as semaglutide (GLP-1 only)

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GLP-1 is secreted physiologically by enteroendocrine L-cells of the small and large intestine, and GIP is secreted by duodenojejunal K-cells in response to food intake [23]