Frataxin deficiency is associated with imbalances in iron-sulfur containing proteins, mitochondrial respiratory chain dysfunction and lower ATP production, and accumulation of iron in the mitochondria, which increases oxidative stress and oxidative damage to macromolecules of the respiratory chain (77)
Hence, antioxidants against inflammation and oxidative stress have been used to manage other disorders such as Alzheimers disease, Parkinsons disease, Huntingtons disease, autism, schizophrenia, and depression [23,24,25,26,27,28]
NBL Gluta Marine Collagen Lycopene Complex 6
Covalent or non-covalent inhibitors are again attracting attention, and they target site-specifically a cysteine residue near the active pocket of druggable proteins