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Novo Nordisks PIONEER I and II study, Rybelsus produced weight loss of 3.8 to 4.4 kg after 26 weeks using 14 mg of the drug.[4][5] This compares to the 5.0 to 5.3 kg loss observed in the Rybelsus arm in Lexarias Phase Ib study using 3 mg and later 7 mg of Rybelsus, suggesting that there may be features of this population that make it different from the enrolled population in the PIONEER studies and the impact of small cohort sizes

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