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potentially fatal disturbances of cardiac conduction (widening of QRS), arrhythmias & seizures due to Na channel block (cardiac & CNS) Pharmacokinetics: PO, metabolized in the liver (P450 - 2D6)

In five patients who did not receive dexamethasone treatment, a severe phenotype accompanied by tendon tear or rupture was observed, and the total incidence proportion declined from 0.75% to 0.43% with dexamethasone (Supplementary Table S5)

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