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These reports have provided new hints into the role of AR in pathophysiology of skeletal muscle, as the loss of polyamines is involved in muscle wasting and sarcopenia [44, 45]

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Unfortunately, despite its high prevalence, a large number of MASLD cases remain undiagnosed, often leading to a diagnosis of cryptogenic cirrhosis, where MASH is the underlying condition once other etiological factors for chronic liver disease, such as alcohol abuse, viral hepatitis, autoimmune disorders, and other metabolic diseases, have been excluded [23]