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however, each treatment had at least one study with over 1000 participants (SURMOUNT-1 for tirzepatide, SCALE Obesity and Prediabetes for liraglutide, and STEP 1 for semaglutide)

Similar to the reversible ADP-ribosylation of proteins and DNA, the ADP-ribosylation of RNA can also be efficiently reversed by several cellular hydrolases including TARG1, MACROD1-2, PARG, NUDT16 and ARH3 viruses

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