This mutation involved a protein called alpha B-crystallin
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YAP/TAZ activates inflammatory pathways such as STAT3 and NF-B, promoting the release of the pro-inflammatory factors like IL-6, IL-17, and TNF-, thereby forming a keratinocyte-immune cell positive feedback loop that exacerbates psoriatic pathology [48,49,50,51]
Some patients may experience mild fatigue or low energy , especially when starting treatment
