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Cell proliferation of cultured tendon fibroblasts derived from rat Achilles tendon was not directly affected by BPC-157, as evaluated by MTT assay

The peptide's small molecular weight (0.39 kDa) enables it to interact directly with DNA and act as an epigenetic regulatory factor, modulating chromatin structure and gene accessibility in neural tissue

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Notably, mice in the RGD-Lip group developed hypothermia after the third dose, whereas mice in the other groups showed no changes in body temperature and otherwise appeared normal, suggesting that the readministration of RGD-Lip induces immune responses (Fig