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Description

Hepatomas are exquisitely sensitive to pharmacologic ascorbate (P-AscH-)

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Although mechanisms describing the interaction between the key pathway constituents Nrf2, Keap1 and p62 are widely reviewed and discussed in literature, quantitative dynamic models bringing together these mechanisms with time-resolved data are limited

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NQO1: NAD(P)H:quinone oxidoreductase 1

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10.1056/NEJMoa1401731 21 DorsamR

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