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A distinct biological advantage All mammalian cells secrete IGF Binding Proteins (IGFBPs) which bind to and inhibit native IGF-I

Cost and Scale: Chemical synthesis is suited for producing small to medium quantities efficiently and with high purity, driving some preference during manufacturing for clinical trials and for therapies of smaller indications

it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters

Tripartite combination of candidate pandemic mitigation agents: vitamin D, quercetin, and estradiol manifest properties of medicinal agents for targeted mitigation of the COVID-19 pandemic defined by genomics-guided tracing of SARS-CoV-2 targets in human cells