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Chen H, Nie P, Li J, Wu Y, Yao B, Yang Y, et al

Additionally, 1,25(OH)D promotes the expansion and functional enhancement of regulatory T cells (Tregs), not only by directly upregulating FoxP3 and the anti-inflammatory cytokine IL-10, but also by inducing a tolerogenic phenotype in dendritic cells, thereby indirectly facilitating Treg induction [168,169,170,171,172,173].Furthermore, 1,25(OH)D inhibits the mTORC1 pathway and activates fatty acid oxidation, creating a favorable metabolic milieu for Treg differentiationa combined epigeneticmetabolic regulatory mechanism that is emerging as a central feature of Vitamin Dmediated immunomodulation [174, 175]

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Your immune system has two main branches of response which are:1,2,3 Innate or nonspecific immunity: Innate immunity is a rapid, nonspecific response system that is your first line of defense against invaders designed to actively clear or eliminate pathogens