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A randomized, placebo-controlled study in 52 subjects (mean age, 30 years) with relapsing-remitting multiple sclerosis found an increase in total antioxidant capacity in blood with lipoic acid supplementation (1,200 mg/day for 12 weeks) yet not in the activity of specific antioxidant enzymes (superoxide dismutase and glutathione peroxidase) (97)

A large share of the published literature originates from one research group, using a comparatively narrow set of models

LINC00336 is upregulated as a competitive endogenous RNA in lung cancer, and its deletion significantly increases intracellular iron, Fe2+, and lipid ROS levels, leading to ferroptosis [79]

In our experience, if you use proper sterile procedures and refrigerated storage, you can continue sampling from the same reconstituted vial for 3+ months