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The guideline is designed as a living document that will be updated as new real-world and long-term evidence emerges. In effect, the WHO is saying: the benefits are real, but we must continue to study safety, durability, and what happens when treatment stops. Where there is evidence for GLP-1 efficacy and safety, the WHO notes that existing studies are at serious risk of bias and are of either low or very low quality

Regular check-ins with your healthcare provider help determine the appropriate duration for your specific situation and monitor for any ongoing retatrutide side effects

Most patients begin noticing subtle but consistent improvements within 3 to 6 weeks

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