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243 Moreover, BM-MSCs had the ability to restore AFC in an ex vivo perfused human lung, which was partially attributed to the increased sodium-dependent resolution of alveolar edema

The lower alpha diversitybut not serum LPS levelsalso correlated with increased intestinal permeability, measured by a plasma lactulose/rhamnose ratio 90 min after ingestion of the sugar solution, which is a less validated way to assess intestinal permeability because this one sampling point does not take into account renal clearance

Add GIP receptor activation, as Tirzepatide does, and you layer in improved insulin sensitivity, enhanced fat metabolism, and what appears to be reduced GI side effects compared to GLP-1-only approaches