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Furthermore, the EMA has withdrawn the weight loss medication rimonabant, a selective cannabinoid type 1 receptor antagonist, due to its reported links to increased risks of depression and suicide [70]

Oral formulations are anticipated to gain faster acceptance among patients seeking non-injectable options for long-term therapy use

And more recently, prescription NAD+ therapies delivered via nasal spray, like Midi's NAD+ Nasal Spray, have emerged as an alternative to oral supplements and IV clinics

Therefore, medications like Ozempic are generally most effective when incorporated into a comprehensive weight management plan or a permanent change like surgery