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Unlike natural GLP-1, which breaks down in 1-2 minutes, the modified peptide has a longer half-life, ranging from hours to days

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Either it can be through redox reaction in reduction of peroxides by thiol peroxidases or most common reversible modification, S-glutathionylation by thiol transferases or in conjugation reactions of toxic metabolites through glyoxalase or a variety of other compounds by glutathione-S-transferases

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