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Overexpression of MDM2 results in decreased level and activity of p53 (Kubbutat et al, 1997) and provides an alternative to a p53 mutation in the sense that it inactivates p53

Sbraccia, P., Aberle, J., Olsen, A

The Pediatric Neurology Advisory Committee in 1996 and some textbooks and manuals strongly recommended carnitine supplementation (50100 mg/kg per day) during VPA therapy for children at risk for developing a carnitine deficiency, in VPA overdose and in VHT [33, 92, 93]

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