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Reiter R: Oxidative damage in the central nervous system: protection by melatonin

Antinociceptive and Analgesic Effects DSIP demonstrated a potent antinociceptive effect when administered intracerebroventricularly or intracisternally in rodent models establishing central analgesic activity independent of peripheral opioid mechanisms

As to whether oxidative stress contributes to the sclerosing ductal lesions, its involvement in primary sclerosing cholangitis is worth registering (43), in that similar lesions are not infrequently present in patients with ordinary chronic pancreatitis (18)

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