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Specifically, exposure to cold temperatures stimulates a metabolic shift, thereby coordinating cholesterol conversion to bile acids in the liver via an alternative synthesis pathway

The ability of HO-1 to protect against SARS-CoV-2 infection is probably an emergency inducible defense mechanism to ameliorate OxS from heme-released oxidants 27

These values increased when perfusion imaging was studied alone, with 92% specificity and 80% sensitivity in terms of HT prediction (126)