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Reproduced from Wilding et al

The American Medical Association's code of ethics is clear: clinical decisions must be based on 'sound scientific evidence'

A doctor determines the appropriate dose and schedule based on an individual's health needs

Dennis Gross himself: Gently press up from the base to dispense the desired amount and apply directly to the lips, starting at the fullest part of your lips and staying inside the natural lip border Apply it either to bare lips or over your lip color of choice Apply product as needed throughout the day Note that its common to feel a slight tingle upon first application, though I only found that to be the case within the first few seconds